Helix 3–helix 5 interactions in steroid hormone receptor function
نویسندگان
چکیده
منابع مشابه
A critical role of helix 3-helix 5 interaction in steroid hormone receptor function.
The ligand-binding domains of steroid hormone receptors possess a conserved structure with 12 alpha-helices surrounding a central hydrophobic core. On agonist binding, a repositioned helix 12 forms a pocket with helix 3 (H3) and helix 5 (H5), where transcriptional coactivators bind. The precise molecular interactions responsible for activation of these receptors remain to be elucidated. We prev...
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ژورنال
عنوان ژورنال: The Journal of Steroid Biochemistry and Molecular Biology
سال: 2008
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2008.03.018